Middle East respiratory syndrome
Identifieur interne : 000144 ( Main/Exploration ); précédent : 000143; suivant : 000145Middle East respiratory syndrome
Auteurs : Ziad A. Memish [Arabie saoudite, États-Unis] ; Stanley Perlman [États-Unis] ; Maria D. Van Kerkhove [Suisse] ; Alimuddin Zumla [Royaume-Uni]Source :
- Lancet (London, England) [ 0140-6736 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Anticorps monoclonaux (usage thérapeutique), Antiviraux (usage thérapeutique), Chameaux, Complications de la grossesse et maladies infectieuses (), Complications de la grossesse et maladies infectieuses (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient, Enfant, Facteurs de risque, Femelle, Grossesse, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Immunité innée (physiologie), Infection croisée (), Infection croisée (transmission), Infection croisée (épidémiologie), Infections à coronavirus (), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Lutte contre l'infection, Plasma sanguin, Santé mondiale, Soins de réanimation, Sujet immunodéprimé, Techniques de laboratoire clinique, Vaccins antiviraux, Voyage, Zoonoses (transmission), Épidémies.
- MESH :
- physiologie : Immunité innée.
- usage thérapeutique : Anticorps monoclonaux, Antiviraux, Hormones corticosurrénaliennes, Infection croisée, Infections à coronavirus, Zoonoses.
- épidémiologie : Complications de la grossesse et maladies infectieuses, Infection croisée, Infections à coronavirus.
- Adulte, Animaux, Chameaux, Complications de la grossesse et maladies infectieuses, Coronavirus du syndrome respiratoire du Moyen-Orient, Enfant, Facteurs de risque, Femelle, Grossesse, Humains, Infection croisée, Infections à coronavirus, Lutte contre l'infection, Plasma sanguin, Santé mondiale, Soins de réanimation, Sujet immunodéprimé, Techniques de laboratoire clinique, Vaccins antiviraux, Voyage, Épidémies.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Adult, Animals, Antibodies, Monoclonal (therapeutic use), Antiviral Agents (therapeutic use), Camelus, Child, Clinical Laboratory Techniques, Coronavirus Infections (epidemiology), Coronavirus Infections (prevention & control), Coronavirus Infections (transmission), Critical Care, Cross Infection (epidemiology), Cross Infection (prevention & control), Cross Infection (transmission), Epidemics, Female, Global Health, Humans, Immunity, Innate (physiology), Immunocompromised Host, Infection Control, Middle East Respiratory Syndrome Coronavirus, Plasma, Pregnancy, Pregnancy Complications, Infectious (epidemiology), Pregnancy Complications, Infectious (prevention & control), Risk Factors, Travel, Viral Vaccines, Zoonoses (transmission).
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones, Antibodies, Monoclonal, Antiviral Agents.
- epidemiology : Coronavirus Infections, Cross Infection, Pregnancy Complications, Infectious.
- physiology : Immunity, Innate.
- prevention & control : Coronavirus Infections, Cross Infection, Pregnancy Complications, Infectious.
- transmission : Coronavirus Infections, Cross Infection, Zoonoses.
- Adult, Animals, Camelus, Child, Clinical Laboratory Techniques, Critical Care, Epidemics, Female, Global Health, Humans, Immunocompromised Host, Infection Control, Middle East Respiratory Syndrome Coronavirus, Plasma, Pregnancy, Risk Factors, Travel, Viral Vaccines.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.
Url:
DOI: 10.1016/S0140-6736(19)33221-0
PubMed: 32145185
PubMed Central: 7155742
Affiliations:
- Arabie saoudite, Royaume-Uni, Suisse, États-Unis
- Angleterre, Grand Londres, Géorgie (États-Unis), Iowa
- Iowa City, Londres
- University College de Londres, Université de l'Iowa
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Le document en format XML
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Memish</name><affiliation wicri:level="1"><nlm:aff id="aff1">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Research Center, King Saud Medical City Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. 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Coronavirus</term><term>Plasma</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious (epidemiology)</term><term>Pregnancy Complications, Infectious (prevention & control)</term><term>Risk Factors</term><term>Travel</term><term>Viral Vaccines</term><term>Zoonoses (transmission)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Antiviraux (usage thérapeutique)</term><term>Chameaux</term><term>Complications de la grossesse et maladies infectieuses ()</term><term>Complications de la grossesse et maladies infectieuses (épidémiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Immunité innée (physiologie)</term><term>Infection croisée ()</term><term>Infection croisée (transmission)</term><term>Infection croisée (épidémiologie)</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Lutte contre l'infection</term><term>Plasma sanguin</term><term>Santé mondiale</term><term>Soins de réanimation</term><term>Sujet immunodéprimé</term><term>Techniques de laboratoire clinique</term><term>Vaccins antiviraux</term><term>Voyage</term><term>Zoonoses (transmission)</term><term>Épidémies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Antibodies, Monoclonal</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Immunité innée</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Immunity, Innate</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antiviraux</term><term>Hormones corticosurrénaliennes</term><term>Infection croisée</term><term>Infections à coronavirus</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications de la grossesse et maladies infectieuses</term><term>Infection croisée</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Camelus</term><term>Child</term><term>Clinical Laboratory Techniques</term><term>Critical Care</term><term>Epidemics</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Immunocompromised Host</term><term>Infection Control</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Plasma</term><term>Pregnancy</term><term>Risk Factors</term><term>Travel</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Chameaux</term><term>Complications de la grossesse et maladies infectieuses</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infection croisée</term><term>Infections à coronavirus</term><term>Lutte contre l'infection</term><term>Plasma sanguin</term><term>Santé mondiale</term><term>Soins de réanimation</term><term>Sujet immunodéprimé</term><term>Techniques de laboratoire clinique</term><term>Vaccins antiviraux</term><term>Voyage</term><term>Épidémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stöhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van 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uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, R" uniqKey="Taylor R">R Taylor</name></author><author><name sortKey="Kotian, P" uniqKey="Kotian P">P Kotian</name></author><author><name sortKey="Warren, T" uniqKey="Warren T">T Warren</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Iowa</li></region><settlement><li>Iowa City</li><li>Londres</li></settlement><orgName><li>University College de Londres</li><li>Université de l'Iowa</li></orgName></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></noRegion><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name></region><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></country><country name="Suisse"><noRegion><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name></region><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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